The Lab for Scalable Mental Health, housed within Northwestern University and directed by Dr. Jessica Schleider (Associate Professor of Medical Social Sciences, Pediatrics, and Psychology), conducts research at the intersection of digital health, public health, dissemination and implementation science, and clinical psychology. The Lab’s mission is to create, evaluate, and disseminate brief, scalable supports that bridge historically-unfillable gaps in mental health ecosystems, with a focus on serving youth underserved by traditional models of care. LSMH has pioneered a new area of intervention science—single-session interventions (SSIs) for mental health—that opens tangible paths toward reducing mental health problems at scale. Via multiple federal, foundation, and industry-funded grants, LSMH has led dozens of clinical trials and large-scale evaluations of digital and lay provider-delivered SSIs. Through these initiatives, LSMH’s SSIs have served more than 100,000 young people to date.